AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory

🌰 Wisdom in a Nutshell

Essential insights distilled from the video.

1. Grape seed extract benefits vascular function, but resveratrol's lifespan extension claims are debunked.
2. NAD supplementation and infusions can enhance energy, but health is a multi-faceted approach.
3. Exploring drugs targeting mTOR for lifespan extension, but data is inconclusive.
4. Quality life and longevity depend on basics like healthy diet, exercise, and sleep.

📚 Introduction

In the pursuit of longevity, there are many myths and misconceptions surrounding certain compounds and practices. This blog post aims to debunk these myths and provide a deeper understanding of the science behind aging. We will explore the role of resveratrol, NAD, and various drugs in extending lifespan, while emphasizing the importance of the basics in maintaining a healthy and fulfilling life.

🔍 Wisdom Unpacked

Delving deeper into the key ideas.

1. Grape seed extract benefits vascular function, but resveratrol's lifespan extension claims are debunked.

Resveratrol, found in grape seed extract, has been debunked as a potential lifespan extender. While it may have positive effects on cell function, there is little direct evidence. Grape seed extract, containing resveratrol, is beneficial for vascular function and blood flow. It is not a top recommendation for supplementation, especially with limited budgets. Resveratrol does not directly increase longevity in humans, but there is a focus on NAD-related pathways for increasing lifespan. NAD is a pathway within cells that is highly active in young animals and humans, related to cellular energetics and mitochondrial function. NR and NMN are considered precursors to NAD.

2. NAD supplementation and infusions can enhance energy, but health is a multi-faceted approach.

NAD, a molecule found in every cell of our body, plays a crucial role in energy metabolism and is associated with longevity. There are three ways to increase NAD levels: supplementation, taking NMN, and infusing NAD. While the effectiveness of these methods is debated, they can potentially enhance mental and physical energy. However, it's important to understand that supplements should not be the sole focus of health and well-being. Light exposure, movement, nutrition, stress modulation, and social relationships are equally important. Additionally, drugs like metformin and berberine, commonly discussed in the longevity sphere, are still being researched for their impact on lifespan.

3. Exploring drugs targeting mTOR for lifespan extension, but data is inconclusive.

The use of drugs like metformin and rapamycin, which target mTOR, is being explored for their potential to extend lifespan. While there is some evidence, the data is not yet conclusive. Rapamycin, an anti-cancer drug, is being studied in various species, including dogs, for its ability to extend lifespan. However, the speaker, who is not taking these drugs, is open to considering them in the future. They currently use grape seed extract, NR, and NMN to support their health and occasionally receive NAD infusions to increase NAD levels directly.

4. Quality life and longevity depend on basics like healthy diet, exercise, and sleep.

The foundation of a quality life and a long life is based on the basics, such as a healthy diet, regular exercise, and getting enough sleep. These factors can have a significant impact on overall health and well-being. However, it is also important to stay open to new information and experiences, as they can shape our understanding and approach to life. Ultimately, the key to a long and fulfilling life is a combination of the basics and a willingness to adapt and learn. Before considering supplements or drugs, focus on getting these basics right, including quality nutrition, social connection, stress modulation, and morning sunlight. Consult a board-certified physician before making any changes to your regimen.

💡 Actionable Wisdom

Transformative tips to apply and remember.

While the search for longevity may lead us to various compounds and practices, it is crucial to prioritize the basics of a healthy lifestyle. Focus on consuming a nutritious diet, engaging in regular physical activity, and prioritizing quality sleep. Additionally, nurture meaningful social connections and manage stress effectively. Stay open to new information, but always consult a healthcare professional before considering supplements or drugs.

📽️ Source & Acknowledgment

Link to the source video.

This post summarizes Andrew Huberman's YouTube video titled "AMA #12: Thoughts on Longevity Supplements (Resveratrol, NR, NMN, Etc.) & How to Improve Memory". All credit goes to the original creator. Wisdom In a Nutshell aims to provide you with key insights from top self-improvement videos, fostering personal growth. We strongly encourage you to watch the full video for a deeper understanding and to support the creator.